Culture of EV71 virus in wave bioreactor system for production of hand, foot and mouth disease vaccine

Adenovirus in EV71-associated hand, foot, and mouth disease.

Sir—Jane Cardosa and colleagues (Sept 18, p 987) report the discovery of a new fastidious adenovirus among patients with suspected hand, foot, and mouth disease (HFMD) in Sarawak. Subsequent to that outbreak, at least five deaths among young children with almost similar clinical presentations were reported in the Malaysian Peninsula. Enterovirus 71 (EV71) was isolated and identified in all five...

Freeze-drying of foot and mouth disease virus and its application in inactivated virus vaccine production

Five different subtypes of foot and mouth disease (FMD) virus propagated in BHK21 C13 monolayer cell cultures, namely 05, A5/!0, A22, C¡ and Asia 1/1, were used to study the stability of live virus during freeze-drying and subsequent storage. Binary ethyleneimine-inactivated FMD virus vaccines adjuvanted with purified saponin, "Quil-A", without aluminium hydroxide gel, were examined before and ...

Clinical features of severe cases of hand, foot and mouth disease with EV71 virus infection in China

INTRODUCTION Hand, foot and mouth disease (HFMD) caused by EV71 infection has become one of the major public health issues in China, which deeply affects children's health. The prevention and control of EV71 is a challenge currently because there is no safe and effective vaccine or antiviral medications available. MATERIAL AND METHODS A case control study was conducted in a designated hospita...

The situation of foot and mouth disease virus types and subtypes in Iran in 1980-1983

Hand Foot and Mouth Disease

Hand foot and mouth disease is an acute viral illness caused by the Coxsackie virus. The contagious nature of the disease is threatening as the disease primarily affects the children of school going age. As the name suggests, typical lesions will be seen over the hands, feet and in the oral cavity. The child gets irritated, febrile and lethargic. Oral lesions can add up to the general weakness ...